Microsoft's Infrastructure Updates have been out for about a week now. There does seem to be some potential big issues with the updates breaking third party products. Microsoft also has posted a KB article on Alternate Access Mappings issues associated with the Infrastructure updates.
Here are a few key posts you should be looking at if you have installed or are considering installing the Infrastructure Updates:
AAM issue with Infrastructure Update
Description of the Infrastructure Update for Windows SharePoint Services 3.0: July 15, 2008
KB: When is the SPContext.Current available ? (SharePoint dev)